Muamba, 24, collapsed on the pitch during a televised encounter between Bolton and Tottenham at White Hart Lane in March and the game was abandoned as medics fought to save his life.
His heart stopped for 78 minutes but the former midfielder made a remarkable recovery, spending four weeks in an east London hospital.
He said he hoped to return to professional football, but following further surgery in Belgium last week doctors have informed the former England Under-21 international that he should not play again.
Muamba said: “Since suffering my heart attack and being discharged from hospital, I have remained utterly positive in the belief I could one day resume my playing career and play for Bolton Wanderers once again

“As part of my on-going recovery, last week I travelled to Belgium to seek further medical advice from a leading cardiologist. But the news I received was obviously not what I had hoped it would be and it means I am now announcing my retirement from professional football.
“Football has been my life since I was a teenage boy and..